The MED8 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MED8. This antibody recognizes Human, Mouse, and Rat antigen. The MED8 Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins